▶ 주요학력

1991-1995 : 부산대학교 자연과학대학 미생물학과 이학사
1996-1998 : 부산대학교 일반대학원 미생물학과 이학석사 (생화학)
1999-2003 : 부산대학교 일반대학원 미생물학과 이학박사 (생화학)

▶ 전공분야

전공-연구분야 : 해부학
강의분야 : 인체의 구조와 기능
학위논문 : Mechanism of Cerebrovascular Dysfunction and Gene Therapy in Brain Traumatic Injury and Subarachnoid Hemorrhage

▶ 연구분야

Stroke and neurovascular regulation

▶ 주요경력

2003년 10월부터 2007년 10월까지 Massachusetts General Hospital, Harvard Medical School 박사후연수
2007년 11월부터 2008년 8월까지 부산대학교 허혈조직재생연구센터 연구교수
2008년 9월부터 2009년 2월까지 부산대학교 허혈조직재생연구센터 기금교수
2009년 3월부터 현재까지 부산대학교 한의학전문대학원 한의학과 조교수

▶ 수상경력

▶ 가입학회

The member of Society for Neuroscience
The member of American Heart Association and American Stroke Association
The member of International Society for Cerebral Blood Flow & Metabolism

▶ 연구실적

[국외전문학술지]

1.Shin HK, Lee HR, Lee DH, Hong KW, Lee JH, Park SY, Lee SJ, Lee JS, Lee WS, Rhim BY, Kim CD, Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia, Journal of Neuroscience Research, in press
2. Park SY, Lee SW, Shin HK, Lee WS, Chung WT, Rhim BY, Hong KW, Kim CD, Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-HO-1 induction, Arthritis and Rheumatism 62(3): 732-741, 2010
3. Lee SJ, Kim CE, Yun MR, Seo KW, Park HM, Yun JW, Shin HK, Bae SS, Kim CD, 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK, Toxicology and Applied Pharmacology 242(2): 191-198, 2010
4. Jang JY, Lee JH, Shin HK, Choi YH, Lee JD,Choi BT, Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10 cells, International Journal of Molecular Medicine 25 : 287-292, 2010
5. Park JY*, Shin HK*, Choi YW, Lee YJ, Bae SS, Han J, Kim CD, Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells, Journal of Ethnopharmacology 125(2) : 291-296, 2009 (*contributed equally)
6. Park SY, Shin HK, Kim CD, Lee WS, Rhim BY, Hong KW, Cilostazol ameliorates metabolic abnormalities with suppression of proinflammatory markers in a db/db mouse model of type 2 diabetes via activation of peroxisome proliferator-activated receptor gamma transcription, The Journal of Pharmacology and Experimental Therapeutics 329(2) : 571-579, 2009
7. Jeong YI, Kim SW, Jung ID, Lee JS, Chang JH, Lee CM, Chun SH, Yoon MS, Kim GT, Ryu SW, Kim JS, Shin YK, Lee WS, Shin HK, Lee JD, Park YM, Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the janus-activated kinase-protein kinase Cδ-stat1 signaling pathway in interferon-γ-stimulated murine dendritic cells, Journal of Biological Chemistry 284(6): 3700-3708, 2009
8. Park JY*, Shin HK*, Lee YJ, Choi YW, Bae SS, Chi Dae Kim CD, The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta, Journal of Ethnopharmacology 121(1): 69-73, 2009 (*contributed equally)
9. Lee JH, Shin HK, Park SY, Kim CD, Lee WS, Hong KW, Cilostazol preserves CA1 hippocampus and enhances generation of immature neuroblast in dentate gyrus after transient forebrain ischemia in rats, Experimental Neurology 215: 87-94, 2009
10. Shin HK, Salomone S, Ayata C, Targeting cerebrovascular Rho-kinase in stroke, Expert Opinion on Therapeutic Targets 12(12): 1547-1564, 2008
11. Jones PB, Shin HK, Boas DA, Hyman BT, Moskowitz MA, Ayata C, Dunn AK, Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia, Journal of Biomedical Optics 13(4): 044007-1-044007-11, 2008
12. Park SY, Lee JH, Shin HK, Kim CD, Lee WS, Rhim BY, Hong KW, Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive species and inflammatory markers in cultured human coronary artery endothelial cells, The Korean Journal of Physiology & Pharmacology 12(4): 165-170, 2008
13. Shin HK, Nishimura M, Jones PB, Ay H, Boas DA, Moskowitz MA, Ayata C, Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia, Stroke 39(5): 1548-1555, 2008
14. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S, Linking Notch signaling to ischemic stroke, Proceedings of the National Academy of Sciences USA; 105(12): 4856-4861, 2008
15. Lee JH, Park SY, Shin HK, Kim CD, Lee WS, Hong KW, Protective Effects of Cilostazol against Transient Focal Cerebral ischemia and Chronic Cerebral Hypoperfusion Injury, CNS Neuroscience & Therapeutics 14(2): 143-152, 2008
16. Nishimura M, Izumiya Y, Higuchi A, Shibata R, Qiu J, Kudo C, Shin HK, Moskowitz MA, Ouchi N, Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase-dependent mechanisms, Circulation 117(2): 216-223, 2008
17. Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C, Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy, Brain 130(9): 2310-2319, 2007 (Cover paper)
18. Atochin DN, Wang A, Liu VWT, Critchlow JD, Dantas APV, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL, The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo, The Journal of Clinical Investigation 117(7): 1961-1967, 2007
19. Shin HK, Jones PB, Dunn AK, Boas DA, Moskowitz MA, Ayata C, Normobaric hyperoxia improvescerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischemia, Brain 130(6): 1631-1642, 2007
20. Lee JH, Park SY, Shin HK, Kim CD, Lee WS, Hong KW, Poly(ADP-ribose)polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat, Brain Research 1152: 182-190, 2007
21. Shin HK, Salomone S, Potts EM, Lee SW, Millican E, Noma K, Huang PL, Boas DA, Liao JK, Moskowitz MA, Ayata C, Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms, Journal of Cerebral Blood Flow and Metabolism 27(5): 998-1009, 2007
22. Shin HK, Dunn AK, Jones PB, Boas DA, Moskowitz MA, Ayata C, Vasoconstrictive neurovascular coupling during focal ischemic depolarization, Journal of Cerebral Blood Flow and Metabolism 26(8) : 1018-1030, 2006 (Cover paper)

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[단행본]

[연구보고서]

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