▶ 주요학력
93-00 : 건국대학교 수의학과 (수의학사)
00-02 : 서울대학교 의과대학 의학과 생리학교실 (생리학전공; 의학석사)
02-05 : 서울대학교 의과대학 의학과 생리학교실 (생리학전공; 의학박사)
▶ 전공분야
전공 : 양방생리학
강의분야 : 양방생리학
학위논문 : TRPM7 is required for intestinal pacemaking activity.
▶ 연구분야
-Ion channel signaling in gastrointestinal tract
(carbachol-activated n0nselective cationic current)
-Pacemaking activity in gastrointestinal tract
(Interstitial Cells of Cajal)
-Transient Receptor Potential (TRP) Channel
(TRPC4, TRPC5, TRPM7)
-Apoptotic mechanism of cancer cell
▶ 주요경력
-2005/09 - 2006/02
Postdoctoral Fellow, 서울대학교 의과대학 인간생명과학연구단 (BK21)
-2006/04 ? 2008/04
Postdoctoral Fellow, 과학기술부지정 창의적 연구진흥사업 (생체인공근육연구단)
-2008/06 ? present
BK assistant professor, 서울대학교 의과대학 의생명과학연구단 (BK21)
-2019.3.1-2020.1.20
University of Nevada, Reno (UNR). College of Medicine Department of Physiology. Visiting Scholar.
▶ 수상경력
-2005/07/07
The Japan Society of Smooth Muscle Research, The Hiroshi Kuriyama Award
-2007/09/05
The 21st International Symposium on Neurogastroenterology and Motility, Samsung Travel Award
▶ 가입학회
대한생리학회
한국평활근학회
▶ 연구실적
[국외전문학술지]
1. Kim HJ, Jun I, Yoon JS, Jung J, Kim YK, Kim WK, Kim BJ, Song J, Kim SJ, Nam JH, Lee MG. Selective serotonin reuptake inhibitors facilitate ANO6 (TMEM16F) current activation and phosphatidylserine exposure. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2015
2. Kim HS, Lee JH, Park HS, Lee GS, Kim HW, Ha KT, Kim BJ. Schizandra chinensis extracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway. PHARMACEUTICAL BIOLOGY 53(2):212-219, 2015
3. Hwang MW, Ahn TS, Hong NR, Jeong HS, Jung MH, Ha KT, Kim BJ. Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice. WORLD JOURNAL OF GASTROENTEROLOGY 21(4):1117-1124, 2015
4. Hwang MW, Kim BJ. Apoptotic effects and involvement of trpm7 channels of the traditional herbal medicine, Dangkwisoo-san in gastric cancer cells. INTERNATIONAL JOURNAL OF PHARMACOLOGY 10(7):398-405, 2014
5. Youm JB, Leem CH, Lee SR, Song IS, Kim HK, Heo HJ, Kim BJ, Kim N, Han J. Modeling of stochastic behavior of pacemaker potential in interstitial cells of Cajal. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 116(1):56-59, 2014
6. Kim BJ, Nam JH, Kim KH, Joo M, Ha TS, Weon KY, Choi S, Jun JY, Park EJ, Wie J, So I, Nah SY. Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34(3):873-890, 2014
7. Hwang MW, Lee JH, Kim BJ. Carthami flos depolarizes the interstitial cells of cajal and increases the motility in gastrointestinal tract. INTERNATIONAL JOURNAL OF PHARMACOLOGY 10(5):248-257, 2014
8. Kim BJ, Kim HW, Lee GS, So I, Kim SJ. Effects of San-Huang-Xie-Xin-tang, a traditional Chinese prescription for clearing away heat and toxin, on the pacemaker activities of interstitial cells of Cajal from the murine small intestine. Journal of Ethnopharmacology 155(1):744-752, 2014
9. Kim MC, Lee HJ, Lim B, Ha KT, Kim SY, So I, Kim BJ. Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 33(6):1657-1663, 2014
10. Kim SY, Hong C, Wie J, Kim E, Kim BJ, Ha KT, Cho NH, Kim IG, Jeon JH, So I. Reciprocal positive regulation between TRPV6 and NUMB in PTEN-deficient prostate cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447(1):192-196, 2014
11. Park HS, Hong C, Kim BJ, So I. The Pathophysiologic Roles of TRPM7 Channel. The Korean Journal of Physiology & Pharmacology 18(1):15-23, 2014
12. Hwang MW, Lee HJ, Song HJ, Kim BJ. Involvement of MAPKs and PLC Pathways in Modulation of Pacemaking Activity by So-Cheong-Ryong-Tang in Interstitial Cells of Cajal from Murine Small Intestine. SCIENTIFIC WORLD JOURNAL 2013:1-10, 2013
13. Kim BJ, Kim HW, Lee GS, Choi S, Jun JY, So I, Kim SJ. Poncirus trifoliate fruit modulates pacemaker activity in interstitial cells of Cajal from the murine small intestine. JOURNAL OF ETHNOPHARMACOLOGY 149(3):668-675, 2013
14. Nam JH, Kim WK, Kim BJ. Sphingosine and FTY720 Modulate Pacemaking Activity in Interstitial Cells of Cajal from Mouse Small Intestine. Molecules and Cells 36(3):235-244, 2013
15. Hwang MW, Kim JN, Song HJ, Lim B, Kwon YK, Kim BJ. Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal. World J Gastroenterol 19(14):2249-2255, 2013
16. Kim BJ. Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells. J Ginseng Res 37(2):201-209, 2013
17. Kim BJ, Kwon YK, Kim E, So I. Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine. Korean J Physiol Pharmacol 17(2):149-156, 2013
18. Lee JH, Kim SY, Kwon YK, Kim BJ, So I. Characteristics of the Cholecystokinin induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine. Cell Physiol Biochem 31(4-5):542-554, 2013
19. Kim BJ, Nam JH, Kwon YK, So I, Kim SJ. The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker. Basic Clin Pharmacol Toxicol 112(2):83-89, 2013
20. Hwang MW, Kim HW, Kim BJ. Involvement of transient receptor potential melastatin 7 channels in orostachys japonicus-induced apoptosis in cancer cells. International Journal of Pharmacology 8(27):638-646, 2012
21. Seo BD, Kim BJ, Singh K. The comparison of resistance and balance exercise on balance and falls efficacy in older females. European Geriatric Medicine 3(5):312-316, 2012
22. Kim BJ. The role of ginseng total saponin in transient receptor potential melastatin type 7 channels. ANIM CELLS SYST 16(5):376-384, 2012
23. Kim BJ, Jang IY, So I. Pharmacological Differences of Endothelin Receptors-mediated Modulation in Cultured Interstitial Cells of Cajal from the Murine Small and Large Intestine. Cell Physiol Biochem 30(2):359-371, 2012
24. Kim BJ, Jang IY, Choi S, Jun JY, Jeon JH, Xu WX, Kwon YK, Ren D, So I. Involvement of Na +-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cell Physiol Biochem 29(3-4):501-510, 2012
25. Han S, Kim JS, Jung BK, Han SE, Nam JH, Kwon YK, Nah SY, Kim BJ. Effects of ginsenoside on pacemaker potentials of cultured interstitial cells of cajal clusters from the small intestine of mice. Mol. Cells. 33(3):243-249, 2012
26. Kim BJ, Kim SY, Lee S, Jeon JH, Matsui H, Kwon YK, Kim SJ, So I. The role of transient receptor potential channel blockers in human gastric cancer cell viability. Can J Physiol Pharmacol 90(2):175-186, 2012
27. Lee BH, Choi SH, Shin TJ, Hwang SH, Kim HJ, Kim BJ, Nah SY. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res 36(1):55-60, 2012
28. Kim BJ, Nam JH, Kim SJ. Effects of Transient Receptor Potential Channel Blockers on Pacemaker Activity in Interstitial Cells of Cajal from Mouse Small Intestine. Mol. Cells. 32(2):153-160, 2011
29. Park EJ, Kim SY, Kim SH, Lee CR, Kim IS, Park JK, Lee SW, Kim BJ, Chun JN, So I, Jeon JH. SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells. Biochim Biophys Acta 1813(12):2157-2164, 2011
30. Kim BJ, Nah SY, Jeon JH, So I, Kim SJ. Transient Receptor Potential Melastatin 7 Channels are Involved in Ginsenoside Rg3-Induced Apoptosis in Gastric Cancer Cells. Basic Clin Pharmacol Toxicol 109(4):233-239, 2011
31. Lee HT, Kim BJ. Trimebutine as a modulator of gastrointestinal motility. Arch. pharm. res 34(6):861-864, 2011
32. Sung TS. Jeon JP, Kim BJ, Hong C. Kim SY, Kim J. Jeon JH, Kim HJ, Suh CK, Kim SJ, So I. Molecular determinants of PKA-dependent inhibition of TRPC5 channel. Am J Physiol Cell Physiol 301(4):823-832, 2011
33. Kim BJ. Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer. ANIM CELLS SYST 15(2):123-130, 2011
34. Kim SH, Bae HC, Park EJ, Lee CR, Kim BJ, Lee S, Park HH, Kim SJ, So I, Kim TW, Jeon JH. Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochem Biophys Res Commun 407:129-134, 2011
35. Kim MT, Park WJ, Kim S, Lee JW, Lee SY, Jeon JH, So IS, Kim BJ, Kim SJ. Involvement of Calmodulin Kinase II in the Action of Sulphur Mustard on the Contraction of Vascular Smooth Muscle. Basic Clin Pharmacol Toxicol 108(1):28-33, 2011
36. Kim YM, Kim SA, Lee SM, Choi YJ, Kim BJ, Shin NS. Canine behavioral problems and their effect on relinquishment of the Jindo dog. J Vet Sci 11(4):345-350, 2010
37. Kim BJ, Chae H, Kwon YK, Choi S, Jun JY, Jeon JH, So I, Kim SJ. Effects of imatinib mesylate in interstitial cells of cajal from murine small intestine. Biol Pharm Bull 33(6):993-997, 2010
38. Jung JH*, Kim BJ*, Chae MR, Kam SC, Jeon JH, So I, Chung KH, Lee SW. Gene transfer of TRPC6 (dominant negative) restores erectile function in diabetic rats. J SexMed 7(3):1126-38, 2010 (*co-first author)
39. Choi S, Yeum CH, Kim YD, Park CG, Kim MY, Park JS, Jeong HS, Kim BJ, So I, Kim KW. Receptor tyrosine and MAP kinase are involved in effects of H(2)O(2) on interstitial cells of Cajal in murine intestine. J Cell Mol Med 14(1-2):257-66, 2010
40. Kim BJ, Park KJ, Kim HW, Choi S, Jun JY, Chang IY, Jeon JH, So I, Kim SJ. Identification of TRPM7 channels in human intestinal interstitial cells of Cajal. World J Gastroenterol 15(46):5799-804, 2009
41. Kim BJ, Lee SY, Kim HW, Park EJ, Kim J, Kim SJ, So I, Jeon JH. Optimized immunohistochemical analysis of cerebellar purkinje cells using a specific biomarker, calbindin d28k. Korean J Physiol Pharmacol 13(5):373-8, 2009
42. Park EJ*, Kim BJ*, Kim SH, Kim SY, Sung TS, Chae HG, Kim SJ, Kim J, Park HH, So I, Jeon JH. Altered biochemical properties of transient receptor potential vanilloid 6 calcium channel by peptide tags. Biol Pharm Bull 32(10):1790-4, 2009 (*co-first author)
43. Park EJ, Kim SH, Kim BJ, Kim SY, So I, Jeon JH. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr 44(2):125-30, 2009
44. Sung TS, Kim MJ, Hong S, Jeon JP, Kim BJ, Jeon JH, Kim SJ, So I. Functional characteristics of TRPC4 channels expressed in HEK 293 cells. Mol Cells 27(2):167-73, 2009
45. Kim SH, Nam JH, Park EJ, Kim BJ, Kim SJ, So I, Jeon JH. Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells. Biochimica et Biophysica Acta Molecular Basis of Disease. 1792(1):33-38, 2009
46. Shin MK, Kim SH, Jung S, Kim SI, Kim SJ, Kim BJ, So I. The effect of DNA on mechanical properties of nanofiber hydrogels. Applied Physics Letters. 93, 171903-5, 2008
47. Shin MK, Kim SI, Kim SJ, Kim BJ, So I, Kozlov ME, Oh J, Baughman RH. A tough nanofiber hydrogel incorporating ferritin. Applied Physics Letters. 93, 163902-4, 2008
48. Kim YM, Choi YJ, Kim SH, El-Aty AM, Kim BJ, Hwang SH, Lee SM. Response to a combined treatment program with clomipramine, behavioral, and environmental management of compulsive tail chasing in a German Shepherd. Berl Munch Tierarztl Wochenschr. 121(9-10):329-33, 2008
49. Jeon JP, Lee KP, Park EJ, Sung TS, Kim BJ, Jeon JH, So I. The specific activation of TRPC4 by Gi protein subtype. Biochem Biophys Res Commun. 377(2): 538-543, 2008
50. Kim BJ, Park EJ, Lee JH, Jeon JH, Kim SJ, So I. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Science 99(12): 2502-2509, 2008
[국내전문학술지]
1. 홍누리, 안태석, 박현수, 채한, 권영규, 김병주. 생쥐 소장 카할세포의 내향성 향도잡이 전압에 미치는 내소산의 억제효과에 관한 연구. 동의생리병리학회지 28(6):630-635, 2014
2. 채한, 김성혜, 한승윤, 이상재, 김병주, 권영규, 이수진. 사상 소화기능 소증에 따른 체질별 생리심리 특성 연구. 동의생리병리학회지 28(4):417-424, 2014
3. 김정남, 채한, 권영규, 김병주. 오미자의 유방암 세포사멸과 TRPM7 관련성에 관한 연구. 동의생리병리학회지 28(2):162-168, 2014
4. 김병주. Shengmaisan Regulates Pacemaker Potentials in Interstitial Cells of Cajal in Mice. Journal of Pharmacopuncture 16(4):36-42, 2013
5. 김현설, 김병주. 위장관 질환의 치료를 위한 한의학 연구 동향. 동의생리병리학회지 27(5):570-577, 2013
6. 이희정, 김민철, 임보라, 김병주. Buxus Microphylla var. Koreana Nakai Extract for the Treatment of Gastric Cancer. Journal of Pharmacopuncture 16(3):39-45, 2013
7. 김병주, 김형우, 이금산. Involvement of TRPM7 channels on Poncirus fructus induced depolarizations of pacemaking activity in interstitial cells of Cajal from murine small intestine. integrative medicine research 2:62-69, 2013
8. 한은경, 황상문, 서수연, 정윤임, 배고은, 김병주, 이상재, 채한, 권영규. 한의학적 임상영양치료법 개발을 위한 연구. 동의생리병리학회지 27(4):350-361, 2013
9. 임보라, 이희정, 김민철, 김병주. Effects of Ulmi Pumilae Cortex on AGS Gastric Cancer Cells. Journal of Pharmacopuncture 16(2):56-63, 2013
10. 류정현, 김병주, 김형우. Anti-Allergic Effect of Ulmus davidiana Cortex on Contact Dermatitis Induced by Dinitrofluoro- Benzene in Mice. Journal of Pharmacopuncture 16(2):41-45, 2013
11. 김정남, 송호준, 임보라, 권영규, 김병주. Modulation of Pacemaker Potentials by Pyungwi-San in Interstitial Cells of Cajal from Murine Small Intestine- Pyungwi-San and Interstitial Cells of Cajal -. 대한약침학회지 16(1):43-49, 2013
12. 김정남, 권영규, 김병주. Effects of Samchulkunbi-tang in Cultured Interstitial Cells of Cajal of Murine Small Intestine. 동의생리병리학회지 27(1):112-117, 2013
13. 김미영, 김한나, 이미란, 김병주, 최찬헌, 정현우, 김형우. 1-fluoro-2,4 dinitrobenzene처리 방법이 피부염 유발에 미치는 영향. 동의생리병리학회지 26(5):693-698, 2012
14. 김병주. Involvement of Transient Receptor Potential Melastatin 7 Channels in Sophorae Radix-induced Apoptosis in Cancer Cells - Sophorae Radix and TRPM7 -. 대한약침학회지 15(2):31-38, 2012
15. 김민철, 임보라, 이희정, 김형우, 권영규, 김병주. Effects of Sophorae Radix on Human Gastric and Colorectal Adenocarcinoma Cells -Sophorae Radix and Cancer Cells-. 대한약침학회지 15(2):15-19, 2012
16. 김한나, 김미영, 최찬훈, 김병주, 김경윤, 김계엽, 정훈우, 김형우. Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice. 대한약침학회지 15(2):7-10, 2012
17. 김병주. Antioxidative, Antiaging and Whitening Effects of the Korean Herbal Bathing Candidate. Journal of Lifestyle Medicine 2(1):36-40, 2012
18. 임보라, 이희정, 김민철, 김형우, 김병주. 인체 위암세포에서 고삼의 세포사멸효과. 한국한의학연구원논문집 18(1):85-92, 2012
19. 이희정, 김민철, 임보라, 배고은, 김형우, 권영규, 김병주. 고삼의 인체 유방암세포에 미치는 효과. 한국한의학연구원논문집 18(1):75-84, 2012
20. 김민철, 이희정, 임보라, 김형우, 김병주. 고삼의 인체 대장암세포에 미치는 효과. 동의생리병리학회지 26(2):155-159, 2012
21. 한송이, 김정아, 송호준, 채한, 권영규, 김병주. 홍화가 인체 대장암세포에 미치는 효과. 한국한의학연구원논문집 17(2):129-134, 2011
22. 권영규, 송호준, 김정아, 한송이, 김형우, 채한, 김병주. 홍화가 위장관 카할간질세포에 미치는 효과. 동의생리병리학회지 25(4):603-607, 2011
23. 김정아, 한송이, 송호준, 채한, 권영규, 김병주. 홍화가 인체 위암세포에 미치는 효과. 동의생리병리학회지 25(3):466-470, 2011
24. 채한, 이수진, 이용재, 김병주, 권영규. 한의학 입문과정에서의 소집단 찬반토론 개발 연구. 동의생리병리학회지 25(2):326-333, 2011
25. 한승헌, 채한, 권영규, 김병주. 한의약 제품의 연구개발 현황 및 산업화 전략. 한국한의학연구원논문집 17(1):99-108, 2011
26. 김병주, 서인석. Functional Analysis of TRPV6 Polymorphisms. Laboratory Animal Research 26(4):331-337, 2010
27. 한승헌, 김정수, 정보경, 박소정, 김형우, 채한, 권영규, 김병주. 한방 입욕제 처방이 피부 병변 모델에 미치는 영향. 한국한의학연구원논문집 16(3):107-113, 2010
28. 정보경, 박소정, 김정수, 한승헌, 손경우, 윤미영, 이선경, 이상재, 김병주, 권영규, 채한. 한방 기능성 입욕제 SP1과 SP2의 항산화, 항노화, 미백효과에 관한 연구. 동의생리병리학회지 24(5):837-842, 2010
29. 권영규, 채한, 이수진, 박소정, 김병주, 홍진우, 황민우, 이상남, 한창현. SCL-90-R을 사용한 사상체질별 심리정신 특성 연구. 동의생리병리학회지 24(4):722-726, 2010
30. 김병주, 홍진우, 황민우, 채한, 권영규. 위장관 질환의 연구전략수립을 위한 최근 5년간 한의약논문의 체계적 고찰. 동의생리병리학회지 23(6):1273-1281, 2009
31. 홍진우, 김영인, 박소정, 김병철, 엄일규, 황민우, 신상우, 김병주, 권영규, 채한. 사상체질 진단검사를 위한 데이터마이닝 알고리즘 연구. 동의생리병리학회지 23(6):1234-1240, 2009
32. 김형우, 김병주, 임세현, 김현영, 이숙영, 조수인, 김영균. 포공영 추출물의 항산화 효과 및 피부 각질세포 보호효과. 대한본초학회지 24(8):108-113, 2009
33. 채한, 황상문, 엄일규, 김병철, 김영인, 김병주, 권영규. 신경망을 사용한 사상체질 진단검사 개발 연구. 동의생리병리학회지 23(4):765-771, 2009
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