▶ 주요학력

78-86 연세대학교 공과대학 생명공학과 공학사
87-89 연세대학교 공과대학 생명공학과 공학석사(미생물학)
89-92 연세대학교 공과대학 생명공학과 공학박사(분자생물학)

 

▶ 전공분야

전공-연구분야 : 분자생물학, 세포생물학
강의분야 : 분자생물학, 세포생물학, 생화학, 미생물학
학위논문 : 호알칼리성 Bacillus sp.의 bacteriolytic enzyme 유전자와 효소의 작용기작

 

▶ 연구분야

1. 당뇨병 및 인슐린저항성과 관련된 유전자의 전사조절에 관한 연구 
2. Histone methylation에 의한 지방세포 분화 조절 연구

3. 갈색지방세포의 기능 및 browning 조절 연구

4. 비알코올성 지방간 발병에 있어서 histone methylation 역할 연구

5. 대사기능 조절을 통한 당뇨병, 비알코올성지방간 개선 한약재 연구

 

 

▶ 주요경력

1992. 03.~1994. 12. University of Texas Health Science Center, Postdoctoral felllow
1995. 01.~1996. 12. University of Texas Health Science Center, Instructor
1997. 01.~1997. 07. University of Texas Health Science Center, Assistant Professor
1997. 10.~2002. 03. 국립보건원 종양연구과 보건연구관
2002. 04.~2007. 08. 국립보건원 대사영양질환과 과장
2007. 08.~2012. 08. 부산대학교 한의학전문대학원 한의학과 조교수
2012. 09.~2016. 08. 부산대학교 한의학전문대학원 한의학과 부교수
2016. 09.~ 현재      부산대학교 한의학전문대학원 한의학과 교수

 

 

▶ 수상경력

1. 2002. 10 국립보건원 우수과제상

2. 2003. 4 국립보건원 우수과제상

3. 2006. 1 국립보건연구원 최우수논문상

4. 2007. 4 국립보건연구원 최우수논문상

5. 2007. 5 대한당뇨병학회 우수연제상

 

▶ 가입학회

한국분자세포생물학회
대한생화학회
대한당뇨병학회

 

▶ 연구실적

 

[국외전문학술지]

1. Jang MK, Yun YR, Kim JH, Park MH, Jung MH. Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity. 2017. Sci Rep. 2017. 9;7.

2. Jang MK, Kim JH, Jung MH. Histone H3K9 Demethylase JMJD2B Activates Adipogenesis by Regulating H3K9 Methylation on PPARγ and C/EBPα during Adipogenesis. PLoS One. 2017. 6;12(1).

3. Yun YR, Kim JH, Kim JH, Jung MH. Protective effects of gomisin N against hepatic steatosis through AMPK activation. Biochem Biophys Res Commun. 2017. 482(4). 1095.

4. Kim H, Kim HJ, Yang D, Jung MH, Kim BJ. Depolarizing Effects of Daikenchuto on Interstitial Cells of Cajal from Mouse Small Intestine. Pharmacogn Mag. 2017. 13(49):141.

5. Jang MK, Lee S, Jung MH. RNA-Seq Analysis Reveals a Negative Role of KLF16 in Adipogenesis. PLoS One. 2016. 9;11.

6. Jang MK, Nam JS, Kim JH, Yun YR, Han CW, Kim BJ, Jeong HS, Ha KT, Jung MH. Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress. J Ethnopharmacol. 2016. 185. 96.

7. Jang MK, Yun YR, Kim SH, Kim JH, Jung MH. Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis. Biol Pharm Bull. 2016. 39(5). 832.

8. Kim HJ, Park SY, Kim DG, Park SH, Lee H, Hwang DY, Jung MH, Ha KT, Kim BJ. Effects of the roots of Liriope Platyphylla Wang Et tang on gastrointestinal motility function. J Ethnopharmacol. 2016. 184. 144.

9. Kim HJ, Kim H, Jung MH, Kwon YK, Kim BJ. Berberine induces pacemaker potential inhibition via cGMP-dependent ATP-sensitive K+ channels by stimulating mu/delta opioid receptors in cultured interstitial cells of Cajal from mouse small intestine. Mol Med Rep. 2016. 14(4). 3985.

10. Seo HS, Lee DJ, Chung JH, Lee CH, Kim HR, Kim JE, Kim BJ, Jung MH, Ha KT, Jeong HS. Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7. BMC Complement Altern Med. 2016. 16.187.

11. Jang MK, Han YR, Nam JS, Han CW, Kim BJ, Jeong HS, Ha KT, Jung MH. Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress. Int J Mol Sci. 2015.16(11). 6151.

12. Jang MK, Jung MH. ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells. Biochem Biophys Res Commun. 2015. 456(1). 80.

13. Park HS, Hong NR, Ahn TS, Kim H, Jung MH, Kim BJ. Apoptosis of AGS human gastric adenocarcinoma cells by methanolic extract of Dictamnus. Pharmacogn Mag. 2015. S329-36.

14. Hong NR, Park HS, Ahn TS, Jung MH, Kim BJ. Association of a Methanol Extract of Rheum undulatum L. Mediated Cell Death in AGS Cells with an Intrinsic Apoptotic Pathway. J Pharmacopuncture. 2015. 18(2). 26.

15. Lee HJ, Jo S, Ryu J, Jeong HS, Lee G, Ryu MH, Jung MH, Kim H, Kim BJ. Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice. Mol Med Rep. 2015. 12(2). 2135.

16. Jang MK, Jung MH. ATF3 represses PPARγ expression and inhibits adipocyte differentiation. Biochem Biophys Res Commun. 2014. 454(1). 58. 64.

17. Son Y, Jang MK, Jung MH. Vigna nakashimae extract prevents hepatic steatosis in obese mice fed high-fat diets. J Med Food. 2014. 17(12). 1322.

18. Nam JS, Chung HJ, Jang MK, Jung IA, Park SH, Cho SI, Jung MH. Sasa borealis extract exerts an antidiabetic effect via activation of the AMP-activated protein kinase. Nutr Res Pract. 2013. 7. 15.

19. Son Y, Nam JS, Jang MK, Jung IA, Cho SI, Jung MH. Antiobesity activity of Vigna nakashimae extract in high-fat diet-induced obesity. Biosci Biotechnol Biochem. 2013. 77(2). 332.

Jang MK, Son Y, Jung MH. ATF3 plays a role in adipocyte hypoxia-mediated mitochondria dysfunction in obesity. Biochem Biophys Res Commun. 2013. 431(3). 421.

20. Jang MK, Kim CH, Seong JK, Jung MH. ATF3 inhibits adipocyte differentiation of 3T3-L1 cells. Biochem Biophys Res Commun. 2012. 421(1). 38.

21. Yeo JY, Ha TJ, Nam JS, Jung MH. Antidiabetic effects of Vigna nakashimae extract in db/db mice. Biosci Biotechnol Biochem. 2011. 75(11). 2223.

22. Jang MK, Park HJ, Jung MH. ATF3 represses PDX-1 expression in pancreatic β-cells. Biochem Biophys Res Commun. 2011. 412(2). 385.

23. Lee JW, Kim WH, Yeo J, Jung MH. ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells. Mol Cells. 2010. 30(6). 545.

24. Park HJ, Kang YM, Kim CH, Jung MH. ATF3 negatively regulates adiponectin receptor 1 expression. Biochem Biophys Res Commun. 2010. 400(1). 72.

25. Kim HB, Kim WH, Han KL, Park JH, Lee J, Yeo J, Jung MH. cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2010. 391(1). 634.

26. Lee H.J., Kang Y.M., Moon C.S., Joe M.K., Lim J.H., Seo Y.H., Song J.H., Jung M.H. Kr㉨ppel-like factor 4 (KLF4) positively regulates human ghrelin expression. 2009. Biochemical J. 2009. 420

27. Lim J.H., Lee H.J., Song J., Jung M.H. (co-corresponding author) Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. 2009. Cellular Signalling (IF: 4.398). 1. 169 
28. Lee J.W., Kim W.H., Lim J. H., Choi K. Y., Jung M.H. Mitochondrial Dysfunction: Glucokinase Downregulation Lowers Interaction of Glucokinase with Mitochondria, Resulting in Apoptosis of Pancreatic beta Cells. 2009. Cellular Signalling (IF: 4.398). 1. 69
29. Joe M.K., Lee H.J., Han K.L., Suh Y.H., Lim J.H., Song J., Jung M.H. Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic -cells. 2008. Cellular Signalling (IF: 4.398), 20, 907

30. Han K.L., Choi J.S., Lee J.Y., Song J., Jung M.H. (co-corresponding author), Jae-Kwan Hwang. Therapeutic potential of PPAR-α/γ dualagonist with alleviation of ER stress for the treatment of diabetes mellitus. 2008. Diabetes (IF: 7.955), 57, 737

31. Kim TM, Jung YC, Rhyu MG, Jung M.H., Chung YJ. GEAR: genomic enrichment analysis of regional DNA copynumber changes. 2008. Bioinformatics. 24, 420
32. Kim T.M., Chung Y.J., Rhyu M.G., Jung M.H. Inferring biological functions and associated transcriptional regulators using gene set expression coherence analysis. 2007. BMC Bioinformatics (IF: 4.958), 8, 453
33. Kim T.M., Chung Y.J., Rhyu M.G., Jung M.H. Germline methylation patterns inferred from local nucleotide frequency of repetitive sequences in human genome. 2007. Mammalian genome (IF: 2.747), 18, 277
34. Kim W.H., Lee J.W., Suh Y.H., Jung M.H. AICAR potentiates ROS production induced by chronic high glucose : Role of AMPK activation on pancreatic-cells. 2007. Cellular Signalling (IF: 4.398), 19, 791
35. Choi J.S., Koh I.U., Jung M.H., Song J. Effects of three different conjugated linoleic acid preparations on insulin signaling, fat oxidation and mitochondrial function in rats fed a high-fat diet. 2007, Br J Nutr (IF: 2.15), 4, 1
36. kim H.B., Kong M.Y., Kim T.M., Seo Y.H., Kim W., Lim J.H., Song J.H., Jung M.H. NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. 2006. Diabetes (IF: 7.955), 55, 1342
37. Lim J.H., Lee J.I., Seo Y.H., Kim W., Song J.H., Jung M.H. Mitochondria dysfunction induces aberrant insulin signaling and glucose utilization in murine C2C12 myotube cells. 2006. Diabetologia (IF: 5.640), 49, 1924
38. Choi J.S., Kang K.R., Song J.H., Jung M.H. Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. 2006, Biol Pharm Bull (IF: 1.525), 29. 306
39. Kim K.Y., Lee J.W., Park M.S., Jung M.H., Jeon G.A., Nam M.J. Expression of a thioredoxin-related protein-1 is induced by prostaglandin E(2). 2006. Int J Cancer (IF: 4.426), 118. 1670
40. Lee Y.M., Choi J.S., Kim M.H., Jung M.H., Lee Y.S., Song J. Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. 2006. Nutrition (IF: 2.342), 22, 956
41. Kim T.M., Jung M.H. Identification of transcriptional regulators using binding site enrichment analysis (BSEA). 2006. In Silico Biology, 6, 531
42. Kim W.H., Lee J.W., Suh Y.H., Hong S.H. Jung M.H. Exposure to chronic high glucose induces beta cell apoptosis through decreased interaction of glucokinase with mitochondria. 2005, Diabetes (IF: 7.955), 54, 2602.
43. Kim W.H., Lee J.W., Gao B. Jung M.H. Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: Apoptosis of pancreatic beta cells via the p53 and ROS pathway. 2005, Cell Signal (IF: 4.398). 17, 1526.
44. Seo Y.H., Kim Y.Y., Choi K.S., Lee J.W. Kim. W. H., Oh T.J., Ahn S. Jung, M.H. Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats. 2005, J. Mol. Endocrinol. (IF: 3.855) 34, 299.
45. Suh Y.H., Kim W.H., Moon C., Hong Y.H., Eun S.Y., Lim J.H., Choi J.S., Song J.H., Jung M.H. Ectopic overexpression of neuronatin potentiates adipogenesis through the enhanced phosphorylation of cAMP responsive element binding protein in 3T3-L1 cells. 2005, Biochim. Biophys. Res. Commun. (IF: 2.855), 337, 481.
46. Choi K.S., Suh Y.H., Kim W.H., Lee J.H. Jung M.H. Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity. 2005, Biochim Biophys. Res. Commun. (IF: 2.855), 328, 206.
47. Han K.L., Jung M.H., Sohn J.H., Hwang J. Ginsenoside 20(S)-protopanaxatriol (PPT) activates Peroxosome Proliferatory-activated receptor gamma (PPAR gamma) in 3T3-L1 adipocytes. 2005, Biol Pharm Bull (IF: 1.525), 29. 110
48. Kim W., Park W.B., Gao B. Jung M.H. Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells. 2004, Mol Pharmacol (IF: 5.080), 66, 1383.
49. Choi J.S., Jung M.H., Park H.S. Song J.H. Effect of conjugate linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. 2004, Nutrition (IF: 2.342), 11, 1008.
50. Choi K.S., Lee T.H. Jung M.H. Ribozyme-mediated cleavage of the human survivin mRNA and inhibition of antiapoptotic function of survivin in MCF-7 cells. 2003, Cancer Gene Therapy (IF: 3.000), 10, 87.

 

[국내전문학술지]

[단행본]

 

[연구보고서]

 

▶ 특허출원